Association of patient survival with clinical characteristics and CD68/CD206 expression features in stage IIIA squamous cell lung carcinoma.

Zlatnik E.Yu. 1Ulyanova E.P. 1Shatova Yu.S. 1Sagakyants A.B. 1Dzhenkova E.A. 1Shevchenko A.N. 1Vitkovskaya V.N. 1Antonyan A.A. 1Kharagezov D.A. 1

1 National Medical Research Centre for Oncology

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Tumor-associated macrophages are an important component of the microenvironment in non-small cell lung cancer; their density and spatial distribution may be associated with the clinical course of the disease. The aim of the study was to evaluate the association of overall survival in patients with stage IIIA squamous cell lung cancer with clinical characteristics and expression patterns of CD68 and CD206 markers in the tumor stroma and parenchyma. The study was performed using material from 31 patients with stage IIIA squamous cell lung cancer who underwent surgery as the first stage of treatment in 2018–2020 at the National Medical Research Centre for Oncology of the Ministry of Health of the Russian Federation. For prognostic assessment, patients were divided according to the median overall survival, which was 42 months, into short-survival and long-survival groups. Immunohistochemical examination was performed using antibodies against CD68 and CD206. Statistical analysis included the Mann–Whitney test, Pearson chi-square test, Fisher exact test, and Spearman correlation coefficient. Higher CD68 expression in the stroma was associated with better overall survival. No statistically significant differences between survival groups were found for CD68 in the parenchyma or CD206 in the studied zones. Among clinical factors, an unfavorable prognosis was associated with pneumonectomy and the presence of comorbidity. In the long-survival group, a significant negative correlation was found between CD68 expression in the stroma and CD206 expression in the parenchyma, whereas no comparable correlation pattern was observed in patients with short survival. The prognostic significance of tumor-associated macrophages in stage IIIA squamous cell lung cancer is determined not only by their density, but also by their spatial organization between the tumor stroma and parenchyma. CD68 expression in the stroma may be considered a potential prognostic marker, and combined assessment of CD68 in the stroma and CD206 in the parenchyma may improve the accuracy of risk stratification for an unfavorable disease course.

squamous cell lung carcinoma

tumor microenvironment

tumor-associated macrophages

cd68 and cd206 markers

overall survival

Conflict of interest

The authors declare no conflict of interest.

Financing

The research was performed without external funding.

Библиографическая ссылка

Антонян А.А., Ульянова Е.П., Харагезов Д.А., Златник Е.Ю., Сагакянц А.Б., Витковская В.Н., Дженкова Е.А., Шатова Ю.С., Шевченко А.Н. ВЗАИМОСВЯЗЬ ВЫЖИВАЕМОСТИ ПАЦИЕНТОВ С КЛИНИЧЕСКИМИ ХАРАКТЕРИСТИКАМИ И ОСОБЕННОСТЯМИ ЭКСПРЕССИИ CD68/CD206 ПРИ ПЛОСКОКЛЕТОЧНОМ РАКЕ ЛЁГКОГО IIIA СТАДИИ. // Современные проблемы науки и образования. 2026. № 6. ;
URL: https://science-education.ru/en/article/view?id=34611 (дата обращения: 27.05.2026).
DOI: https://doi.org/10.17513/spno.34611

Scientific journal
Modern problems of science and education

ISSN 2070-7428

"Перечень" ВАК

ИФ РИНЦ = 0,936