EFFECT OF CORTISONE ACETATE ON RENAL WATER EXCRETION FUNCTION IN NEPHROPATHY

Dzhioev I.G. 1Berezova D.T. 1Avsanova O.T. 1Buzoeva M.R. 1Karsanov T.D. 1Gigolaev A.O. 1

1 North Ossetian State Medical Academy

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Study of exogenous glucocorticoid on the excretory function of the kidneys in conditions of toxic nephritis, as well as decoding of pathophysiological indicators, taking them into account on the basis of the identified shifts. Experiments were performed on 48 sexually mature male Wistar rats equally allocated to control and experimental groups. Cortisone acetate was administered orally at a dose of 1.5 mg/100 g body weight. Chronic nephropathy was induced by three intramuscular injections of the nephrotoxicant glycerol (0.8 ml/100 g) at the beginning, middle, and end of a one-month period. Spontaneously voided urine was collected over six hours in metabolic cages. Serum and urinary creatinine and total protein were measured, along with urea and sodium concentrations in renal tissue homogenates, and volumetric renal blood flow. Statistical processing of intergroup differences, taking into account the normality of their distribution (Shapiro-Wilk), was assessed using the Student's t-test at p<0.05. A single oral dose of cortisone acetate produced a significant diuretic response attributable to concurrent acceleration of glomerular filtration – driven by increased renal perfusion – and attenuation of tubular water reabsorption secondary to a reduction in renal interstitial osmolarity. Plasma creatinine and total protein remained unaltered. Two-week administration nearly doubled the diuretic effect, primarily through more pronounced suppression of tubular reabsorption; this was accompanied by elevated plasma creatinine, increased proteinuria, and decreased total serum protein. Experimental nephropathy was associated with baseline hypercreatininemia, hypoproteinemia, marked proteinuria, and polyuria, all attributable to impaired tubular reabsorption arising from reduced interstitial osmotic pressure. Against this pathological background, both single-dose (2.16-fold relative) and two-week (2.33-fold relative) cortisone acetate administration produced comparable degrees of diuresis enhancement with negligible differences between dosing regimens, suggesting that nephrotoxic injury overrides the duration-dependent hormonal effect on ADH receptor sensitivity.

cortisone acetate

experimental nephropathy

diuresis

glomerular filtration

tubular reabsorption

renal blood flow

Conflict of interest

The authors declare that there is no conflict of interest.

Financing

The work is part of the research work of the North Ossetian State Medical Academy

Библиографическая ссылка

Карсанов Т.Д., Джиоев И.Г., Авсанова О.Т., Гиголаев А.О., Бузоева М.Р., Берёзова Д.Т. ВЛИЯНИЕ КОРТИЗОНА АЦЕТАТ НА ВОДОВЫДЕЛИТЕЛЬНУЮ ФУНКЦИЮ ПОЧЕК ПРИ НЕФРОПАТИИ // Современные проблемы науки и образования. 2026. № 6. ;
URL: https://science-education.ru/en/article/view?id=34610 (дата обращения: 27.05.2026).
DOI: https://doi.org/10.17513/spno.34610

Scientific journal
Modern problems of science and education

ISSN 2070-7428

"Перечень" ВАК

ИФ РИНЦ = 0,936