Настоящая статья посвящена исследованию адипокинов (лептин, резистин, фактор некроза опухоли , адипонектин) и грелина у больных хроническим вирусным гепатитом С на фоне инсулинорезистентности. Установлены факторы, сопряженные с развитием инсулинорезистентности. Активация системы адипоцитокинов проявлялась в увеличении секреции ФНО- α,лептина, резистина, уровень которых был достоверно связан с инсулинорезистентностью, даже у пациентов с нормальным весом. Наиболее информативным показателем в прогнозировании инсулинорезистентности было снижение секреции грелина. Выявленные корреляционные взаимосвязи с ИМТ, отношением ОТ/ОБ; стеатозом печени , инсулином и НОМА-индексом позволяют расценивать снижение уровня грелина и активацию адипокиновой системы как компонент, участвующий в формировании инсулинорезистентности и метаболического синдрома у больных хроническим гепатитом С.
Present article is dedicated to the study of the influence of adipokines (leptin, resistin, the tumor necrosis factor-α , adiponektin) and ghrelin in the patients with chronic hepatitis C with insulin resistance. The factors, combined with the development of insulin resistance, were established. The activation of the adipokines system was manifested in an increase in the secretion of FNO- α, leptin, resistin, whose level was reliably connected with insulin resistance , even in patients with the normal weight. The most informative indicator in predicting insulin resistance was reduced secretion of ghrelin. Revealed correlation interrelations with BMI, waist-to-hip ratio; liver steatosis, by insulin and by HOMA- index allows to regard decrease in ghrelin and activation adipokines system as a component involved in the formation of insulin resistance and metabolic syndrome in patients with chronic hepatitis C.
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