<?xml version="1.0" encoding="UTF-8"?>
<article xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:noNamespaceSchemaLocation="JATS-archive-oasis-article1-4.xsd" article-type="research-article" dtd-version="1.4" xml:lang="ru">
  <front>
    <journal-meta>
      <journal-title-group>
        <journal-title>Журнал Современные проблемы науки и образования</journal-title>
      </journal-title-group>
      <issn>2070-7428</issn>
      <publisher>
        <publisher-name>Общество с ограниченной ответственностью &amp;quot;Издательский Дом &amp;quot;Академия Естествознания&amp;quot;</publisher-name>
      </publisher>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="publisher-id">ART-21928</article-id>
      <title-group>
        <article-title>СОВРЕМЕННЫЕ АСПЕКТЫ ДИАГНОСТИКИ ДИАБЕТИЧЕСКОЙ ПОЛИНЕЙРОПАТИИ</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author">
          <name-alternatives>
            <name xml:lang="ru">
              <surname>Осепьянц</surname>
              <given-names>В.Г.</given-names>
            </name>
          </name-alternatives>
          <name-alternatives>
            <name xml:lang="en">
              <surname>Osepyants</surname>
              <given-names>V.G.</given-names>
            </name>
          </name-alternatives>
          <email>dolce_vika@mail.ru</email>
          <xref ref-type="aff" rid="affdd84d140"/>
        </contrib>
        <contrib contrib-type="author">
          <name-alternatives>
            <name xml:lang="ru">
              <surname>Карпов</surname>
              <given-names>С.М.</given-names>
            </name>
          </name-alternatives>
          <name-alternatives>
            <name xml:lang="en">
              <surname>Karpov</surname>
              <given-names>S.M.</given-names>
            </name>
          </name-alternatives>
          <email>karpov25@rambler.ru</email>
          <xref ref-type="aff" rid="affdd84d140"/>
        </contrib>
        <contrib contrib-type="author">
          <name-alternatives>
            <name xml:lang="ru">
              <surname>Санеева</surname>
              <given-names>Г.А.</given-names>
            </name>
          </name-alternatives>
          <name-alternatives>
            <name xml:lang="en">
              <surname>Saneeva</surname>
              <given-names>G.A.</given-names>
            </name>
          </name-alternatives>
          <email>sun-stav@yandex.ru</email>
          <xref ref-type="aff" rid="affdd84d140"/>
        </contrib>
        <contrib contrib-type="author">
          <name-alternatives>
            <name xml:lang="ru">
              <surname>Александрович</surname>
              <given-names>Г.А.</given-names>
            </name>
          </name-alternatives>
          <name-alternatives>
            <name xml:lang="en">
              <surname>Aleksandrovich</surname>
              <given-names>G.A.</given-names>
            </name>
          </name-alternatives>
          <email>sun-stav@yandex.ru</email>
          <xref ref-type="aff" rid="affdd84d140"/>
        </contrib>
      </contrib-group>
      <aff id="affdd84d140">
        <institution xml:lang="ru">ГБОУ ВПО «Ставропольский государственный медицинский университет Минздрава России»</institution>
        <institution xml:lang="en">Stavropol State Medical University</institution>
      </aff>
      <pub-date date-type="pub" iso-8601-date="2015-05-02">
        <day>02</day>
        <month>05</month>
        <year>2015</year>
      </pub-date>
      <issue>5</issue>
      <fpage>124</fpage>
      <lpage>124</lpage>
      <permissions>
        <license xlink:href="https://creativecommons.org/licenses/by/4.0/">
          <license-p>This is an open-access article distributed under the terms of the CC BY 4.0 license.</license-p>
        </license>
      </permissions>
      <self-uri content-type="url" hreflang="ru">https://science-education.ru/ru/article/view?id=21928</self-uri>
      <abstract xml:lang="ru" lang-variant="original" lang-source="author">
        <p>Разработка и изучение современных методов ранней диагностики диабетической полинейропатии имеют важное клиническое значение. До определенного времени симптомы, признаки и электрофизиологические показатели являлись ключевыми конечными точками при диагностировании диабетической полинейропатии. Однако они не учитывали повреждение мелких нервных волокон, которые поражаются первыми на ранних этапах развития сахарного диабета и даже еще до развития клинических проявлений. Поэтому внедрение новых современных методик, таких как конфокальная микроскопия роговицы и когерентная томография глаза, являются ведущим направлением в настоящее время, позволяющим своевременно выявить и предотвратить прогрессирование заболевания.</p>
      </abstract>
      <abstract xml:lang="en" lang-variant="translation" lang-source="translator">
        <p>Development and study of modern methods for early diagnosis of diabetic polyneuropathy has important clinical implications. For a time the counting of the symptoms, signs and electrophysiological parameters were the key endpoints in the diagnosis of diabetic polyneuropathy. However, they do not take into account the damage to small nerve fibers that are affected first in the early stages of diabetes, even before the onset of clinical manifestations. Therefore, the introduction of modern techniques such as confocal microscopy of the cornea and coherence tomography of the eye, are one of the leading directions in real time, allowing to detect and to prevent progression of the disease.</p>
      </abstract>
      <kwd-group xml:lang="ru">
        <kwd>сахарный диабет</kwd>
        <kwd>диабетическая полинейропатия</kwd>
        <kwd>диагностика</kwd>
      </kwd-group>
      <kwd-group xml:lang="en">
        <kwd>diabetes mellitus</kwd>
        <kwd>diabetic polyneuropathy</kwd>
        <kwd>diagnosis</kwd>
      </kwd-group>
    </article-meta>
  </front>
  <back>
    <ref-list>
      <ref>
        <note>
          <p>1.	Дедов И.И., Удовиченко О.В., Галстян Г.Р. Диабетическая стопа // Практическая Медицина, 2005; 140 с.</p>
        </note>
      </ref>
      <ref>
        <note>
          <p>2.	Дедов И.И., М.В. Шестакова М.В. Алгоритмы специализированной медицинской помощи больным сахарным диабетом. Выпуск 7-й // М: Медиа Сфера, 2015 – 112 с.</p>
        </note>
      </ref>
      <ref>
        <note>
          <p>3.	Демидова И.Ю., Храмилин В.Н., Игнатова О.Ю. Диабетическая дистальная полинейропатия // Эндокринная хирургия 1(2), 2008.</p>
        </note>
      </ref>
      <ref>
        <note>
          <p>4.	Котов С.В. Калинин А., Рудакова И. Диабетическая нейропатия // Медицинская газета.– 2001.  – № 41.</p>
        </note>
      </ref>
      <ref>
        <note>
          <p>5.	Осепьянц В.Г., Александрович Г.А., Карпов С.М., Санеева Г.А. Роль инсулиноре-зистентности в развитии полинейропатии у больных сахарным диабетом 2-го типа (литературный обзор) // Научно-практический рецензируемый журнал «Клиническая неврология» № 1, 2015 г. – С. 29–33.</p>
        </note>
      </ref>
      <ref>
        <note>
          <p>6.	Храмилин В.Н., Демидова И.Ю., Староверова И.Н., Игнатова О.Ю. Диабетическая нейропатия: учебное пособие. Видар-М, 2012. – 128 с.</p>
        </note>
      </ref>
      <ref>
        <note>
          <p>7.	American Diabetes Association and American Academy of Neurology. Report and recommendations of the San Antonio conference on diabetic neuropathy (Consensus Statement). // Diabetes Care. 1988; 11:592–597.</p>
        </note>
      </ref>
      <ref>
        <note>
          <p>8.	Bril V. Electrophysiologic testing. In: textbook of Diabetic Neuropathy.// Thieme 2002: 177–184.</p>
        </note>
      </ref>
      <ref>
        <note>
          <p>9.	Boulton A.J.M., Gries F.A., Jervell J.A. Guidelines for the diagnosis and outpatient managemaent of diadetic peripheral neuropathy. //Diabet. Med. 1998; 15.</p>
        </note>
      </ref>
      <ref>
        <note>
          <p>10.	Boulton A.J.M., Kirsner R.S., Vileikyte L. Neuropathic diabetic foot ulcers // N. Engl. J. Med. Vol. 351. 2004. № 1. P. 48-55.</p>
        </note>
      </ref>
      <ref>
        <note>
          <p>11.	Boulton A.J.M., VinikA.L, Arezzo J.C., Bril V., Feldman E.L., Freeman R., Malik R.A., Maser R.E., Sosenko J.M., Ziegler D. Diabetic neuropathies: a statement by the American Diabetes Association // Diabetes Care. Vol. 28. 2005. № 4. P. 956–962.</p>
        </note>
      </ref>
      <ref>
        <note>
          <p>12.	Casellini C. M., Vinik A.I. Clinical Manifestations and Current Treatment Options for Diabetic Neuropathies.//Endocr Pract. - 2007; 13(5):550-566.</p>
        </note>
      </ref>
      <ref>
        <note>
          <p>13.	Collier A, Reid W, McInnes A, Cull RE, Ewing DJ, Clarke BF. Somatosensory and visual evoked potentials in insulin-dependent diabetics with mild peripheral neuropathy.// Diabetes Res Clin Pract.1988 Sep 5;5(3):171–175.</p>
        </note>
      </ref>
      <ref>
        <note>
          <p>14.	Devigili G., Tugnoli V., Penza P. The diagnostic criteria for small fibre neuropathy: from symptoms to neuropathology // Brain. — 2008. — Vol. 131.— P. 1912–1925.</p>
        </note>
      </ref>
      <ref>
        <note>
          <p>15.	Eaton S. E., Harris N. D., Rajbhandari S. M. Spinal-cord involvement in diabetic peripheral neuropathy. // Lancet 2001  358;35-36.</p>
        </note>
      </ref>
      <ref>
        <note>
          <p>16.	Efron N. The Glenn A. Fry award lecture 2010: Ophthalmic markers of diabetic neuropathy // Optom. Vis. Sci. 2011. V. 88(6). P. 661–683.</p>
        </note>
      </ref>
      <ref>
        <note>
          <p>17.	Gelber D., Pfeifer M., BroadstoneV.Componentsofvarianceforvibratory and thermal thresholdstesting in normaland diabeticsubjects//Diabetes Complications.— 1995.— Vol. 9.— P. 170–176.</p>
        </note>
      </ref>
      <ref>
        <note>
          <p>18.	Gorson K.C., Ropper A.H. Additional causes for distal sensory polyneuropathy in diabetic patients. //J Neurol Neurosurg Psychiatry. – 2006; 77: 354-358.</p>
        </note>
      </ref>
      <ref>
        <note>
          <p>19.	Happich M., John J., Stamenitis S., Clouth J., Polnau D. The quality of life and economic burden of neuropathy in diabetic patients in Germany in 2002 — results from the Diabetic Microvascular Complications (DIMICO) study// Diabetes Res. Clin. Pract. Vol. 81.2008. № 2. P. 223–230.</p>
        </note>
      </ref>
      <ref>
        <note>
          <p>20.	Herman W.H., Kennedy L. Underdiagnosis of peripheral neuropathy in type 2 diabetes // Diabetes Care. Vol. 28. 2005. № 6. P. 1480–1481.</p>
        </note>
      </ref>
      <ref>
        <note>
          <p>21.	Jalbert I., Stapleton F., Papas E., et al. In vivo confocal microscopy of the human cornea. // Br. J. Ophthalmol. — 2003.–Vol. 87.– № 2.–Р. 225–236.</p>
        </note>
      </ref>
      <ref>
        <note>
          <p>22.	Kempler P., Tesfaye S., Chaturvedi N., Stevens L.K., Webb D.J., Eaton S., Kerenyi Zs., Tamas Gy, Ward J.D., Fuller J.H., the EU-RODIABIDDM Complications Study Group. Autonomic neuropathy is associated with increased cardiovascular risk factors: the EURODIAB IDDM Complications Study// Diabet. Med. Vol. 19. 2002. № 11. P. 900–909.</p>
        </note>
      </ref>
      <ref>
        <note>
          <p>23.	Malik R., Kallinikos P., Abbott C.etal. Cornealconfocal microscopy: a non-invasivesurrogate of nervefibre damageand repair in diabetic patients // Diabetologia.— 2003. — Vol. 46,— P. 683–688.</p>
        </note>
      </ref>
      <ref>
        <note>
          <p>24.	Marshall S.M., Flyvbjerg A. Prevention and early detection of vascular complications of diabetes // BMJ. Vol. 333. 2006. № 7566. P. 475–480.</p>
        </note>
      </ref>
      <ref>
        <note>
          <p>25.	Maser R.E., Laudadio C., De Cherney G.S. The effects of age and diabetes mellituson nerve function // J. Am. Geriatr. Soc. 1993. V. 41 (11). P. 1202.</p>
        </note>
      </ref>
      <ref>
        <note>
          <p>26.	Mastropasqua L., Nubile M. Confocal Microscopy of the Cornea. // SLACK Incorporated. USA. – 2002. P. 122.</p>
        </note>
      </ref>
      <ref>
        <note>
          <p>27.	 Mayfield J.A, Sugarman JR. The use of the Semmes-Weinstein monofilament and other threshold tests for preventing foot ulceration and amputation in persons with diabetes. J/ Fam/ Pract. 2000; 49: 517-529.</p>
        </note>
      </ref>
      <ref>
        <note>
          <p>28.	Maurer J.K., Jester J.V. Use of the vivo confocal microscopy to understand the pathology of accidental ocular irritaition. // Toxicol. Pathol. – 1999.–Vol. 27. – № 1. – Р. 44–47.</p>
        </note>
      </ref>
      <ref>
        <note>
          <p>29.	M&amp;#252;ller L., Vrensen G., Pels L. et al. Architecture of human corneal nerves // Invest. Ophthalmol. Vis. Sci. — 1997. — Vol. 38. — P. 985–994.</p>
        </note>
      </ref>
      <ref>
        <note>
          <p>30.	Neuropathies. Pathomechanism, clinical presentation, diagnosis, therapy // Ed. by P. Kempler. Budapest: Springer Scientific Publisher, 2002.</p>
        </note>
      </ref>
      <ref>
        <note>
          <p>31.	Oliveira – Soto L., Efron N. Morphology of corneal nerves using confocal microscopy // Cornea. – 2001. – V. 20. – № 4. – С. 374–384.</p>
        </note>
      </ref>
      <ref>
        <note>
          <p>32.	Paisley A. N., Abbott C. A., Van Schie C. H. M.* and Boulton A. J. M. A comparison of the Neuropen against standard quantitative sensory-threshold measures for assessing peripheral nerve function. // Diabet. Med. 2002; 19: 400-405.</p>
        </note>
      </ref>
      <ref>
        <note>
          <p>33.	Pascuzzi R.M. Peripheral neuropathies in clinical practice. //Med. Clin. N. Аm. 2003; 87: 697-724.</p>
        </note>
      </ref>
      <ref>
        <note>
          <p>34.	Patel S., McLaren J., Hodge D., et al. Normal human keratocyte density and corneal thickness measurement by using confocal microsco0py in vivo. // Invest. ophthalmol.Vis. Sci. – 2001.–Vol.42.–N2.–Р. 333–339.</p>
        </note>
      </ref>
      <ref>
        <note>
          <p>35.	Said G. Diabetic neuropathy — a review // Nat. Clin. Pract. Neurol. Vol. 3. 2007. № 6. P. 331–340.</p>
        </note>
      </ref>
      <ref>
        <note>
          <p>36.	Somodi S., Hahnel C., Slowic C. et al. Confocal in vivo microscopy and confocal laser–scanning fluorescence microscopy in keratoconus. // Ger. J. Ophthalmol. – 1996. – Vol. 5. – № 6.–Р. 518–525.</p>
        </note>
      </ref>
      <ref>
        <note>
          <p>37.	Scott J., Huskisson E.C., Graphic representation of pain. // Pain 1976; 2:175-84).</p>
        </note>
      </ref>
      <ref>
        <note>
          <p>38.	Tavakoli M., Hossain P., Malik R. Clinical applications of corneal confocal microscopy// Clinical. Ophtalmology. — 2008. — № 2. — P. 435–445.</p>
        </note>
      </ref>
      <ref>
        <note>
          <p>39.	Tavakoli M., Marshal A., Thompson L., Efron N., Malik R. Corneal confocal microscopy is reduced and relates to the severity of neuropathy in patients with diabetes // Diabetes care. 30. 2007. P. 1895–1897.</p>
        </note>
      </ref>
      <ref>
        <note>
          <p>40.	Tavee J., Zhov L. Small fiber neuropathy: A burning problem// Cleveland Clinic Journal of Medicine. – 2009. – Vol.76, № 5. – 297–305.</p>
        </note>
      </ref>
      <ref>
        <note>
          <p>41.	Thomas P. Nerve biopsy // Diabet Med. — 1997. — Vol. 16. — P. 351–352.</p>
        </note>
      </ref>
      <ref>
        <note>
          <p>42.	 Valk G.D., Grootenhuis, PA; van Eijk, JT et al., «Methods for assessing diabetic polyneuropathy: validity and reproducibility of the measurement of sensory symptom severity and nerve function tests» // DIABET REC, 47(2), 2000. Pp. 87–95.</p>
        </note>
      </ref>
      <ref>
        <note>
          <p>43.	Varano M., Scassa C., Ripandelli G. et al. New diagnostic tools for macular edema // Doc Opthalmol. 1999. V. 97. P. 373–379.</p>
        </note>
      </ref>
      <ref>
        <note>
          <p>44.	Yoshida A. New examination methods for macular disordersapplication of diagnosis and treatment // Nippon Ganka Zasshi. 2000. V.104. P.899–942.</p>
        </note>
      </ref>
      <ref>
        <note>
          <p>45.	Wygledowska–Promienska D., Rokita–Wala I., Gierek–Ciaciura S. et al/ The alterations in the corneal structure at III/IV stage of keratoconus by means of confocal microscopy and ultrasound biomicroscopy before penetrating keratoplasty. // Klin. Oczna 1999.–Vol.101. – № 6. – Р. 427–432.</p>
        </note>
      </ref>
      <ref>
        <note>
          <p>46.	Ziegler D Diagnosis and management of diabetic peripheal neuropathy // Diabet. Med. 1996. 34-38.</p>
        </note>
      </ref>
      <ref>
        <note>
          <p>47.	Uenda S., Del Cerro M., Rao G. The Epithelial innervations in human cornea. A light and electron microscopic study // The Cornea: transactions of the Word Congress on the Cornea. – New York Raven Press, 1988. – Р. 63– 67.</p>
        </note>
      </ref>
    </ref-list>
  </back>
</article>
