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  <front>
    <journal-meta>
      <journal-title-group>
        <journal-title>Журнал Современные проблемы науки и образования</journal-title>
      </journal-title-group>
      <issn>2070-7428</issn>
      <publisher>
        <publisher-name>Общество с ограниченной ответственностью &amp;quot;Издательский Дом &amp;quot;Академия Естествознания&amp;quot;</publisher-name>
      </publisher>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="publisher-id">ART-21161</article-id>
      <title-group>
        <article-title>ДИНАМИКА КОМПОНЕНТОВ ДЕРМЫ В ОТВЕТ НА ВВЕДЕНИЕ ФИЛЛЕРОВ</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author">
          <name-alternatives>
            <name xml:lang="ru">
              <surname>Могильная</surname>
              <given-names>Г.М.</given-names>
            </name>
          </name-alternatives>
          <name-alternatives>
            <name xml:lang="en">
              <surname>Mogilnaya</surname>
              <given-names>G.M.</given-names>
            </name>
          </name-alternatives>
          <email>fomevg@mail.ru</email>
          <xref ref-type="aff" rid="aff45c7ac5b"/>
        </contrib>
        <contrib contrib-type="author">
          <name-alternatives>
            <name xml:lang="ru">
              <surname>Фомичева</surname>
              <given-names>Е.В.</given-names>
            </name>
          </name-alternatives>
          <name-alternatives>
            <name xml:lang="en">
              <surname>Fomicheva</surname>
              <given-names>E.V.</given-names>
            </name>
          </name-alternatives>
          <email>fomevg@mail.ru</email>
          <xref ref-type="aff" rid="aff45c7ac5b"/>
        </contrib>
        <contrib contrib-type="author">
          <name-alternatives>
            <name xml:lang="ru">
              <surname>Терехов</surname>
              <given-names>А.Я.</given-names>
            </name>
          </name-alternatives>
          <name-alternatives>
            <name xml:lang="en">
              <surname>Terekhov</surname>
              <given-names>A.Ya.</given-names>
            </name>
          </name-alternatives>
          <email>Julia_Blatt@mail.ru</email>
          <xref ref-type="aff" rid="aff54575458"/>
        </contrib>
        <contrib contrib-type="author">
          <name-alternatives>
            <name xml:lang="ru">
              <surname>Блатт</surname>
              <given-names>Ю.Е.</given-names>
            </name>
          </name-alternatives>
          <name-alternatives>
            <name xml:lang="en">
              <surname>Blatt</surname>
              <given-names>Yu.E.</given-names>
            </name>
          </name-alternatives>
          <email>Julia_Blatt@mail.ru</email>
          <xref ref-type="aff" rid="aff54575458"/>
        </contrib>
      </contrib-group>
      <aff id="aff45c7ac5b">
        <institution xml:lang="ru">ГБОУ ВПО «Кубанский государственный медицинский университет»</institution>
        <institution xml:lang="en">Kuban State Medical University</institution>
      </aff>
      <aff id="aff54575458">
        <institution xml:lang="ru">ООО «МЕРЦ ФАРМ»</institution>
        <institution xml:lang="en">Merz Pharma</institution>
      </aff>
      <pub-date date-type="pub" iso-8601-date="2015-04-06">
        <day>06</day>
        <month>04</month>
        <year>2015</year>
      </pub-date>
      <issue>4</issue>
      <fpage>463</fpage>
      <lpage>463</lpage>
      <permissions>
        <license xlink:href="https://creativecommons.org/licenses/by/4.0/">
          <license-p>This is an open-access article distributed under the terms of the CC BY 4.0 license.</license-p>
        </license>
      </permissions>
      <self-uri content-type="url" hreflang="ru">https://science-education.ru/ru/article/view?id=21161</self-uri>
      <abstract xml:lang="ru" lang-variant="original" lang-source="author">
        <p>В эксперименте изучены морфологические преобразования, происходящие в дерме в зоне введения препаратов Радиесс (Merz) и  Люминера (Израиль). Препараты вводили субдермально крысам-самцам в обьеме 0,05 мл, оценку результатов проводили через 2 недели. Срезы  окрашивали гематоксилином и эозином, для избирательного обнаружения ДНК использовали реакцию Фельгена. Для выявления  коллагеновых волокон использованы окраски по Ван-Гизону,  Маллори и Массону (Pears, 1969). С целью типирования фибриллярных структур дермы  была использована окраска пикро-сириусом красным по Dayan et all (1989). Проведена морфометрия микросфер и дана оценка их оптической плотности. Показано, что динамика изменений затрагивает характеристику микросфер, цитогенную строму вокруг них, статус аморфного компонента, причем реакция компонентов дермы на различные филлеры отличается разнонаправленностью.</p>
      </abstract>
      <abstract xml:lang="en" lang-variant="translation" lang-source="translator">
        <p>The morphological transformations taking place in the dermis in the area of drug administration Radiesse (Merz) and Luminaire (Israel) were studied in this experiment. Drugs were injected male rats hypodermically in the volume of 0.05 mL, evaluation of the results was carried out in 2 weeks. Sections were stained with hematoxylin and eosin for selective detection of DNA. For this purpose, Feulgen reaction was used. To identify the collagen fibers coloring according to Van Gieson , Mallory staining and Masson (Pears, 1969) were used. For typing fibrillary structures of the dermis it was used red PIKRA-sirius coloring according to Dayan et all (1989). Morphometry microspheres and evaluation of their optical density were made. It is shown that the dynamics of the changes affect the characteristics of the microspheres, cytogenetic stroma around them, the status of an amorphous component, the reaction of components of dermal on various fillers differs in different directions.</p>
      </abstract>
      <kwd-group xml:lang="ru">
        <kwd>кристаллы гидроксиапатита</kwd>
        <kwd>филллер</kwd>
        <kwd>препараты Радиесс</kwd>
        <kwd>Люминера</kwd>
        <kwd>неоколлагенез в дерме</kwd>
      </kwd-group>
      <kwd-group xml:lang="en">
        <kwd>crystals</kwd>
        <kwd>filller</kwd>
        <kwd>Radiesse products</kwd>
        <kwd>luminaires</kwd>
        <kwd>neocollagenesis in the dermis</kwd>
      </kwd-group>
    </article-meta>
  </front>
  <back>
    <ref-list>
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</article>
